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KMID : 0604520180440010031
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Journal of the Society of Cosmetic Scientists of Korea
2018 Volume.44 No. 1 p.31 ~ p.37
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Behaviour of Nanoemulsions Containing Ceramide IIIB and Stratum Corneum Lipids
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Cho Wan-Goo
Kim Kyung-Ah
Jang Seon-Il
Cho Byoung-Ok
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Abstract
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Oil/water (O/W) nanoemulsions are effective vehicles to change the permeability of the skin. In this study, we focused on the preparation and characterization of nanoemulsion which serve as colloidal carriers for the dermal application of ceramide IIIB (CIIIB) and stratum corneum (SC) lipids such as cholesterol, and palmitic acid. In order to optimize the nanoemulsions, emulsification process conditions were conducted with regard to droplet size, nanoemulsion stability, and solubility of CIIIB. A decrease in droplet size was observed through emulsification temperature of 80 ℃ and phase inversion composition (PIC) method. CIIIB has low solubility in oil and water. When the concentration of CIIIB was increased, the droplet size of nanoemulsion was increased. When Lipoid S75-3 was added to the oil phase, the solubility of CIIIB increased, indicating some interactions shown in DSC measurements. CIIIB and SC lipids could be successfully incorporated in nanoemulsions without crystallization or physical instability. In conclusion, a stable nanoemulsion containing the SC lipids could be effective as an efficient moisturizing system for skin.
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KEYWORD
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ceramides, stratum corneum lipid, nanoemulsion, PIC, HLB
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